How Pro-Xylane™ reinforces collagen XIII and XVII in the epidermis, essential in skin integrity
Collagen XIII is a transmembrane protein belonging to the collagen family, it plays a role in cell adhesion, cell migration and wound healing. Studies indicate that collagen XIII level increase by up to 558%, with AGE RECOVERY NIGHT™ containing Pro-Xylane™.2
How Pro-Xylane™ reinforces collagens in the dermo-epidermal junction, essential in skin firmness
The dermal-epidermal junction is crucial: This part of the skin is responsible for anchoring the epidermis to the dermis. It also facilitates exchanges such as nutrients and oxygen between the 2 skin layers and contributes to wound healing. Ageing causes the functioning of the DEJ (dermal-epidermal junction) to become less efficient, contributing to lines, wrinkles and sagging skin. Pro-Xylane™ reinforces this key layer by increasing the production of at least collagens IV and VII. These two collagens merge to form an anchoring plate that captures the collagen I and III from the dermis, like a Velcro would do to bind the elements together. Studies show that the 2 major collagens on DEJ show an increase of 53% for collagen IV and 25% for collagen VII.2 Besides collagens IV and VII, Pro-XylaneTM also stimulates the production of more minor collagens of the dermo-epidermal junction, namely collagens XV and XVIII.2
The Role of Pro-Xylane™ in the collagens of the deeper layer of the skin
The dermis, which contains fibroblasts responsible for collagen synthesis, sees a significant decline in collagen levels over time. Pro-Xylane™ actively stimulates fibroblasts to produce higher levels of essential collagens, including type I —the most represented collagen in the dermis and primary collagen responsible for skin firmness and elasticity. Studies indicate that collagen I level increase by up to 51%, with AGE RECOVERY NIGHT™ containing 30% Pro-Xylane solution™.2 Besides collagen I, Pro-XylaneTM has proven to stimulate the production of most of the others dermis collagen(V, VI, XI, XII, XIV, XVI)2.
Additionally, Pro-Xylane™ promotes glycosaminoglycan (GAG) synthesis and proteoglycan, components of the extra cellular matrix surrounding the collagen and critical in protection factors key for epidermis growth, retaining moisture and improving skin hydration, directly contributing to plumper, firmer skin.
Scientifically Proven Skin Repair and Anti-Aging Benefits
The efficacy of Pro-Xylane™ is unmistakably demonstrated by extensive clinical research. Results indicate that its application leads to a measurable reduction in wrinkles, improved skin firmness, and enhanced radiance.
- Collagen production: 13 out of 14 types of collagens are activated in all skin layers
- Reduction in ageing signs: Clinical evaluations showed a significant decrease in fine lines, an improvement in radiance, tonicity and firmness.
Why Pro-Xylane™ is the Ultimate Collagen Booster
Different from other collagen-enhancing ingredients, Pro-Xylane™ takes a multi-faceted approach to skin restoration. The concentration of Pro-Xlyane™ also makes a major difference. Helena Rubinstein products contain concentrations of this ingredient sufficient to create a high performing formula, making it the best choice for visible, long-lasting skin rejuvenation.
In strengthening the epidermis, dermo-epidermal junction, and dermis, this brand-patented molecule helps fortify the skin, bring back its firmness, and youthful resilience. With proven clinical results and unrivalled efficacy, Pro-Xylane™ remains a pioneering formulation in the most advanced and efficacious skincare.
1 Tobin DJ. Introduction to skin aging. J Tissue Viability. 2017 Feb;26(1):37-46.
2 Ex-vivo study on human skin explant, collagen synthesis after treatment with Replasty Age Recovery Night alone or post-laser for 3 to 7 days
Audrey Gueniche
– Scientific Director
Audrey GUENICHE is a Doctor in Pharmacy and has a PhD in skin biology. She has a distinguished career of over three decades at L’Oréal in Research and Innovation. Her scientific contributions have been in the areas of topical and food supplements of skin, scalp, hair health and beauty. Audrey’s experience is extensive: from vitro to clinical trials, to open innovation and development. She has published over 130 papers in peer-reviewed journals, presented in 80 international congresses and, additionally, has been recognized and guest speaker in 50 plenary conferences. By embracing an innovative mindset, Audrey is passionate in finding new areas to promote actives and formulas, prove new claims and scientific communications, and reinvent evaluations. As HELENA RUBINSTEIN’s Scientific Director, Audrey pursues the brand’s long-standing avant-garde research and science.
